Fully efficient chromosome dimer resolution in E. coli cells lacking the integral membrane domain of FtsK
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Thank you for submitting your manuscript for consideration by the EMBO Journal. I apologise that it has taken a little longer than usual to have your manuscript reviewed, three referees have evaluated your manuscript and I enclose their reports below, but as you will see the decision was not a straightforward one and I asked other people for their input. The decision unfortunately is not a positive one.
منابع مشابه
Fully efficient chromosome dimer resolution in Escherichia coli cells lacking the integral membrane domain of FtsK.
In bacteria, septum formation frequently initiates before the last steps of chromosome segregation. This is notably the case when chromosome dimers are formed by homologous recombination. Chromosome segregation then requires the activity of a double-stranded DNA transporter anchored at the septum by an integral membrane domain, FtsK. It was proposed that the transmembrane segments of proteins o...
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The septum-located DNA translocase, FtsK, acts to co-ordinate the late steps of Escherichia coli chromosome segregation with cell division. The FtsK gamma regulatory subdomain interacts with 8 bp KOPS DNA sequences, which are oriented from the replication origin to the terminus region (ter) in each arm of the chromosome. This interaction directs FtsK translocation towards ter where the final ch...
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FtsK is a multifunctional protein that acts in Escherichia coli cell division and chromosome segregation. Its C-terminal domain is required for XerCD-mediated recombination between dif sites that resolve chromosome dimers formed by recombination between sister chromosomes. We report the construction and analysis of a set of strains carrying different Xer recombination sites in place of dif, som...
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